Patient
resources.

Explore patient testimonials and educational resources designed to help you. We periodically add new resources to this page. Be sure to check in again soon for new materials.

Actor Portrayals

Videos

Learn About Peter and Kelly’s Journey

Transcript

Peter: My name’s Peter. This is my wife, Kelly. We have two sons in college and a little dog, Lily, and a little cat named Coco.

Kelly: And this was a big year for us because we celebrated our 30th wedding anniversary.

Peter: It’s 30 already?

Kelly: He’s a very funny guy.

Peter: I was first diagnosed in January of 2014. But what happened was I thought I had a pinched nerve in my neck, because my hand seemed a little wonky. So I see my general practitioner and she told me that I should go see a neurologist.

Peter: So I went and saw my neurologist and it turned out that I had Parkinson's.

Peter: It didn't seem real. It seemed like it couldn't be because I felt good. I'd always exercised and I was still exercising.

Talk to your doctor before engaging in exercise to make sure that exercise is right for you.

Kelly: When Peter came home and told me about the diagnosis, we were matter-of-fact about it. We really said, "Okay. Well, what do we do?"

Kelly: But the doc, the neurologist, was very reassuring. Her demeanor and her level of expertise presented it in a very matter-of-fact way so that I don't think it was as devastating to us.

Peter: The treatment that my doctor suggested that we started with was Levodopa-Carbidopa, which worked fairly well for quite a while.

Peter: I had no idea about “off” times til I went to some meetings online with some of the organizations that my doctor suggested I get involved with and talk to the people there, and they were having a presentation about “off” times, and I suddenly realized that I was having the “off” times.

As Parkinson’s disease (PD) progresses, you may experience “off” time. “Off” time is when a patient’s medications for PD are not working well, which can mean that PD symptoms return.

Kelly: I think that we knew things were happening. We just hadn't identified them.

As Parkinson’s disease (PD) progresses, you may experience “off” time. “Off” time is when a patient’s medications for PD are not working well, which can mean that PD symptoms return.

Peter: When I was having an "off" episode, it would kind of...the whole thing. That’d go do the whole arm, would start moving. It’s embarrassing, frankly. So it’s something where you would be sitting somewhere and you’d stick it behind your back, which didn’t do much. But if it’s moving and shaking, it’s uhm…

As Parkinson’s disease (PD) progresses, you may experience “off” time. “Off” time is when a patient’s edications for PD are not working well, which can mean that PD symptoms return.

Kelly: It’s noticeable.

Peter: It’s noticeable.

Peter: It was kind of upsetting because you thought you were doing everything that you could do and it wasn't working the way it had been. And you were having a situation where you were having an "off" time and your body was doing something that you didn't want to do. Your tremors were getting more pronounced.

Peter: So I spoke to my doctor about it…
What the doctor said to me...was that she wanted me to continue with the medications that I was already taking. But to add NOURIANZ...

Individual patient results may vary.

NOURIANZ is a prescription medicine used with levodopa and carbidopa to treat adults with Parkinson’s disease (PD) who are having “off” episodes.

Peter: What my doctor told me to do was to start it with 20 milligrams. We ended up upping it to 40 milligrams.I take it first thing in the morning, which is very convenient and it works for me, it works for my schedule.

Kelly: Made it easier for us to plan things as well, knowing that we could go for longer stretches, and there was more consistency to his day.

Peter: My personal experience is that I have not had any or experienced any side effects from taking NOURIANZ. That might not be typical of every person who uses it. But from my experience, I haven't really been having any side effects.

Individual patient results may vary.

The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness constipation, nausea, hallucinations, and problems sleeping (insomnia).

These are not all the possible side effects of NOURIANZ.

Peter:What I would tell caregivers is to take it one step at a time, because you're going to have hard times. But if you address the problem in front of you as best as you possibly can. And then the next problem you address as best as you possibly can; you just keep finding solutions, the best possible solution.

Kelly: It would be so easy to become overwhelmed when you think about the long run. So it's easier to focus on what you have in front of you and just attack it gradually.

Peter: If you have Parkinson's and you find you're having "off" time, I would strongly suggest you talk to your doctor.

Individual patient results may vary.

Talk to your doctor to find out if NOURIANZ is right for you.

NOURIANZ logo

Talk to your doctor to find out if NOURIANZ is right for you.

What is NOURIANZ?

NOURIANZ is a prescription medicine used with levodopa and carbidopa to treat adults with Parkinson’s disease (PD) who are having “off” episodes.

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you:

have a history of abnormal movement (dyskinesia)
have a history of psychotic thinking or behavior
have reduced liver function
smoke cigarettes or use other tobacco products
are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby
are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.

What are the possible side effects of NOURIANZ?
NOURIANZ may cause serious side effects, including:

uncontrolled sudden movements (dyskinesia). Uncontrolled sudden movements is one of the most common side effects.
hallucinations and other symptoms of psychosis. NOURIANZ can cause abnormal thinking and behavior, including:
- being overly suspicious or feeling people want to harm you (paranoid ideation)
- believing things that are not real (delusions)
- seeing or hearing things that are not real (hallucinations)
- confusion
- increased activity or talking (mania)
- disorientation
- aggressive behavior
- agitation
- delirium (decreased awareness of things around you)
unusual urges (impulse control or compulsive behaviors). Some people taking NOURIANZ get urges to behave in a way unusual for them. Examples of this are unusual urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges.

If you notice or your family notices that you are developing any new or unusual symptoms or behaviors, talk to your healthcare provider.

The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia).

These are not all the possible side effects of NOURIANZ.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see Patient Information for NOURIANZ.

NOURIANZ Overview Video

Transcript

For people with

Parkinson’s disease…

Everyone’s experience

Is different.

Some may have many symptoms.

Example symptoms include:

Stooped posture
Back rigidity
Flexed elbows and wrists
Tremors in the legs
Masked face
Forward tilt of trunk
Reduced arm swing
Hand tremor
Slightly flexed hip and knees
Shuffling, short-stepped gait

And some may only have a few.

Example symptoms include:

Back rigidity
Tremors in the legs
Hand tremor

Parkinson’s symptoms can change over time,

and while no 2 cases are the same…

…the way Parkinson’s disease works in the brain is.

Specific parts of the brain are responsible for controlling movement.

Dopamine is a chemical messenger that helps control these parts of the brain,

And when released, dopamine helps the brain produce movement.

But there is more to movement than dopamine…

There is also adenosine.

Adenosine can attach to different types of receptors, including A2A receptors

That are commonly found in the parts of the brain that control movement.

Dopamine and adenosine are like the pedals in a car.

While dopamine signals the body to move,

Adenosine works to slow movement.

Turning on dopamine receptors is like pushing down on the gas pedal, which speeds up movement.

Turning on adenosine A2A receptors is like applying the brake, which slows movement.

People with Parkinson’s disease may have times throughout each day when Parkinson’s medicines control symptoms well (known as “ON” time)

And times when symptoms return (known as “OFF” time). OFF time may occur at different times throughout the day.

OFF time can be unpredictable and can include symptoms like:

Tremors
Balance problems

OFF time can be unpredictable and can include symptoms like:

Stiffness
Slowness

OFF time can be unpredictable and can include symptoms like:

Reduced dexterity
Trouble getting out of a chair

Despite available treatment options, OFF time occurs in about 50% of people with Parkinson’s disease 5 years after starting treatment.

Parkinson’s disease has usually been managed with treatments like levodopa and carbidopa,

That address the loss of dopamine to help with movement.

NOURIANZ®(istradefylline) is a different way to treat OFF time. Please talk with your doctor to find out if this treatment is right for you.

While the exact way that NOURIANZ works to treat Parkinson’s disease is unknown, it is believed to treat OFF time by blocking adenosine A2A receptors.

Blocking adenosine A2A receptors seems to help release the “brake pedal” that slows down movement.

NOURIANZ is taken with levodopa and carbidopa to treat adults with OFF time.

Levodopa helps replace lost dopamine, like pushing down on the gas,

While NOURIANZ seems to blocks adenosine A2A receptors, which is like releasing the brake.

NOURIANZ is taken once a day, any time of day, with or without food. Work with your healthcare provider to decide what’s best for you.

NOURIANZ comes in 2 strengths. Take NOURIANZ exactly as your healthcare provider tells you.

NOURIANZ is available through any CVS or Walgreens specialty pharmacy.

If you are using levodopa/carbidopa and experiencing OFF time... Ask your doctor if NOURIANZ is right for you. Visit NOURIANZ.com to learn more.

What is NOURIANZ?

NOURIANZ is a prescription medicine used with levodopa and carbidopa to treat adults with Parkinson’s disease (PD) who are having “off” episodes.

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you:

have a history of abnormal movement (dyskinesia)
have a history of psychotic thinking or behavior
have reduced liver function
smoke cigarettes or use other tobacco products
are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby
are breastfeeding or plan to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.

What are the possible side effects of NOURIANZ?
NOURIANZ may cause serious side effects, including:

uncontrolled sudden movements (dyskinesia).Uncontrolled sudden movements is one of the most common side effects.
hallucinations and other symptoms of psychosis.NOURIANZ can cause abnormal thinking and behavior, including:
- being overly suspicious or feeling people want to harm you (paranoid ideation)
- believing things that are not real (delusions)
- seeing or hearing things that are not real (hallucinations)
- confusion
- increased activity or talking (mania)
- disorientation
- aggressive behavior
- agitation
- delirium (decreased awareness of things around you)
unusual urges (impulse control or compulsive behaviors). Some people taking NOURIANZ get urges to behave in a way unusual for them. Examples of this are unusual urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges.

If you notice or your family notices that you are developing any new or unusual symptoms or behaviors, talk to your healthcare provider.

The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia).

These are not all the possible side effects of NOURIANZ.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

NOURIANZ^® (nue’–ree–anz) (istradefylline) tablets, for oral use

What is NOURIANZ?

NOURIANZ is a prescription medicine used with levodopa and carbidopa to treat adults with Parkinson’s disease (PD) who are having “off” episodes.

It is not known if NOURIANZ is safe and effective in children.

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you:

have a history of abnormal movement (dyskinesia).
have reduced liver function.
smoke cigarettes.
are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if NOURIANZ passes into breast milk. You and your healthcare provider should decide if you will take NOURIANZ or breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I take NOURIANZ?

Take NOURIANZ exactly as your healthcare provider tells you to.
Take NOURIANZ one time each day.
You can take NOURIANZ with or without food.
If you take too much NOURIANZ, call your health care provider or go to the nearest hospital emergency room right away.

What are the possible side effects of NOURIANZ?
NOURIANZ may cause serious side effects, including:

uncontrolled sudden movements (dyskinesia). Uncontrolled sudden movements is one of the most common side effects. NOURIANZ may cause uncontrolled sudden movements or make such movements you already have worse or more frequent. Tell your healthcare provider if this happens.
hallucinations and other symptoms of psychosis. NOURIANZ can cause abnormal thinking and behavior including:
- being overly suspicious or feeling people want to harm you (paranoid ideation)
- disorientation
- believing things that are not real (delusions)
- aggressive behavior
- seeing or hearing things that are not real (hallucinations)
- agitation
- confusion
- delirium (decreased awareness of things around you)
- increase activity or talking (mania)
If you have hallucinations or any other abnormal thinking or behavior,talk with your healthcare provider.
unusual urges (impulse control or compulsive behaviors). Some people taking NOURIANZ get urges to behave in a way unusual for them. Examples of this are unusual urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges. If you notice or your family notices that you are developing any unusual behaviors, talk to your healthcare provider.

The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia).

These are not all the possible side effects of NOURIANZ.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

How should I store NOURIANZ?

Store NOURIANZ at room temperature between 68°F to 77°F(20°C to 25°C).
Keep NOURIANZ and all medicines out of the reach of children.

General information about the safe and effective use of NOURIANZ.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use NOURIANZ for a condition for which it was not prescribed. Do not give NOURIANZ to other people, even if they have the same symptoms that you have. It may harm them. You can ask your healthcare provider or pharmacist for information about NOURIANZ that is written for health professionals.

What are the ingredients in NOURIANZ?

Active ingredient: istradefylline

Inactive ingredients: crospovidone, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyvinyl alcohol, hypromellose, polyethylene glycol 3350, titanium dioxide, triacetin, iron oxide red, iron oxide yellow, and carnauba wax.

Manufactured by: Kyowa Kirin Inc., Bedminster, NJ 07921 U.S.

NOURIANZ is a registered trademark of Kyowa Kirin Inc.

For more information, call 1-844-768-3544 or go to www.NOURIANZ.com

How NOURIANZ Works

Transcript

This video is provided for educational purposes only and is not intended to replace discussions with your healthcare provider.

The product information provided in this video is intended only for residents of the US.

In your brain, there are chemicals that occur naturally

to help control movement.

One chemical is dopamine.

Dopamine works like pressing the gas pedal in a car to help your body move.

Adenosine is a different brain chemical that works like pressing the brake pedal to limit movement.

Normally, adenosine and dopamine work together in balance to help you move the way you want to.

However, in Parkinson’s disease, there is too little dopamine activity and too much adenosine activity.

It’s like letting off the gas pedal while pressing on the brake pedal.

This imbalance can cause Parkinson’s symptoms such as difficulty in moving.

Many treatments for Parkinson’s disease, including levodopa/carbidopa, focus on increasing dopamine activity.

But over time, levodopa/carbidopa can start to wear off and stop working well

and Parkinson’s disease symptoms can return.

When this happens, people may experience “off” time.

NOURIANZ^® (istradefylline) is a prescription medicine used with levodopa and carbidopa to treat adults with Parkinson’s disease who are having “off” episodes.

Please continue watching for the full NOURIANZ^® (istradefylline) Important Safety Information and click on link below for the Patient Information.

It is not known if NOURIANZ is safe and effective in children.

Please continue watching for the full NOURIANZ^® (istradefylline) Important Safety Information and click on link below for the Patient Information.

It works differently from other add-on medicines for “off” time.

Please continue watching for the full NOURIANZ^® (istradefylline) Important Safety Information and click on link below for the Patient Information.

NOURIANZ is the first and only treatment

Please continue watching for the full NOURIANZ^® (istradefylline) Important Safety Information and click on link below for the Patient Information.

that lifts the brake of adenosine for “off” time in Parkinson’s disease.

Please continue watching for the full NOURIANZ^® (istradefylline) Important Safety Information and click on link below for the Patient Information.

Although it is unknown how exactly NOURIANZ works,

Please continue watching for the full NOURIANZ^® (istradefylline) Important Safety Information and click on link below for the Patient Information.

it is believed that decreasing adenosine activity...

Please continue watching for the full NOURIANZ^® (istradefylline) Important Safety Information and click on link below for the Patient Information.

is like lifting the brake in a car.

Please continue watching for the full NOURIANZ^® (istradefylline) Important Safety Information and click on link below for the Patient Information.

This helps to increase movement for people experiencing “off” time.

Important Safety Information

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you have a history of abnormal movement (dyskinesia), have a history of psychotic thinking or behavior, have reduced liver function, smoke cigarettes or use other tobacco products, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed. NOURIANZ may harm your unborn baby.

Please continue watching for the full NOURIANZ Important Safety Information and click on link below for the Patient Information.

If you are currently taking levodopa/carbidopa and are experiencing “off” time,

Important Safety Information

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you have a history of abnormal movement (dyskinesia), have a history of psychotic thinking or behavior, have reduced liver function, smoke cigarettes or use other tobacco products, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed. NOURIANZ may harm your unborn baby.

Please continue watching for the full NOURIANZ Important Safety Information and click on link below for the Patient Information.

it may be time to talk to your doctor...

Important Safety Information

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you have a history of abnormal movement (dyskinesia), have a history of psychotic thinking or behavior, have reduced liver function, smoke cigarettes or use other tobacco products, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed. NOURIANZ may harm your unborn baby.

Please continue watching for the full NOURIANZ Important Safety Information and click on link below for the Patient Information.

about lifting the brake of adenosine by adding NOURIANZ.

Important Safety Information

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you have a history of abnormal movement (dyskinesia), have a history of psychotic thinking or behavior, have reduced liver function, smoke cigarettes or use other tobacco products, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed. NOURIANZ may harm your unborn baby.

Please continue watching for the full NOURIANZ Important Safety Information and click on link below for the Patient Information.

Please continue watching for the full NOURIANZ Important Safety Information and see accompanying full prescribing information

See Next Page

Important Safety Information

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you:

have a history of abnormal movement (dyskinesia)
have a history of psychotic thinking or behavior
have reduced liver function
smoke cigarettes or use other tobacco products
are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby
are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.

What are the possible side effects of NOURIANZ?

NOURIANZ may cause serious side effects, including:

uncontrolled sudden movements (dyskinesia). Uncontrolled sudden movements is one of the most common side effects.
hallucinations and other symptoms of psychosis. NOURIANZ can cause abnormal thinking and behavior, including:
- being overly suspicious or feeling people want to harm you (paranoid ideation)
- increased activity or talking (mania)
- believing things that are not real (delusions)
- disorientation
- seeing or hearing things that are not real (hallucinations)
- aggressive behavior
- confusion
- agitation
- delirium (decreased awareness of things around you)
unusual urges (impulse control or compulsive behaviors). Some people taking NOURIANZ get urges to behave in a way unusual for them. Examples of this are unusual urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges. If you notice or your family notices that you are developing any new or unusual symptoms or behaviors, talk to your healthcare provider.

The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia).

These are not all the possible side effects of NOURIANZ.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch

Please see Patient Information for NOURIANZ.

Testimonial video thumbnail link with Parkinson’s patient and care partner”

Learn About Peter and
Kelly’s Journey
Hear from a patient on
NOURIANZ^® (istradefylline) and
a care partner.

NOURIANZ Overview Video
This video provides an overview of NOURIANZ as an option for Parkinson’s disease (PD) and “off” episodes.

Learn About Peter and Kelly’s Journey

How NOURIANZ Works
Watch how NOURIANZ (istradefylline) lifts the brake of adenosine.

Find out more about how to take NOURIANZ

TAKING NOURIANZ

Downloadable Materials

These resources include helpful information about NOURIANZ and the role of adenosine in Parkinson’s disease (PD).

Download the NOURIANZ® (istradefylline) brochure for adults living with Parkinson’s Disease

NOURIANZ BROCHURE

A helpful guide for patients considering NOURIANZ, explaining what it is
and how it works.

Download the NOURIANZ® (istradefylline) Doctor Discussion Guides for adults living with Parkinson’s Disease.

DOCTOR DISCUSSION GUIDE

A tool to help you recognize the impact of the “off” time you may be
experiencing with Parkinson’s disease (PD), and how to talk to your
doctor about it.

Download the Kyowa Kirin and Davis Phinney Wellness team contact information organizer

WELLNESS TEAM CONTACT INFORMATION ORGANIZER

A convenient form to help you keep track of the names, addresses, and
phone numbers of your healthcare providers. Reprinted and provided with
permission by the Davis Phinney Foundation.

Download the Kyowa Kirin and Davis Phinney Foundation Goal Summary for Doctor Visits

GOAL SUMMARY FOR DOCTOR’S VISITS

A useful form to help you set wellness goals with your doctor and track
your progress between visits. Filling out a new form for each doctor visit
can help you create a record of your progress over time. Reprinted and
provided with permission by the Davis Phinney Foundation.

Frequently Asked Questions

What is an “off” episode, or “off” time?
- An “off” episode is a time when a patient’s PD symptoms, such as tremors and difficulty walking, return in between medication doses.
Can NOURIANZ^® reduce “off” time?
- In clinical trials, adult patients with Parkinson's disease (PD) who took NOURIANZ with levodopa, with or without other PD medications, had less “off” time. See NOURIANZ clinical trial results.
What are the possible side effects of NOURIANZ?
- NOURIANZ may cause serious side effects,
  including:
  - uncontrolled sudden movements (dyskinesia). Uncontrolled sudden movements is one of the most common side effects. NOURIANZ may cause uncontrolled sudden movements or make such movements you already have worse or more
    frequent. Tell your healthcare provider if this happens.
  - hallucinations and other symptoms of psychosis. NOURIANZ can cause abnormal thinking and behavior, including:
    - being overly suspicious or feeling people want to harm you (paranoid ideation)
    - believing things that are not real (delusions)
    - seeing or hearing things that are not real (hallucinations)
    - confusion
    - increased activity or talking (mania)
    - disorientation
    - aggressive behavior
    - agitation
    - delirium (decreased awareness of things around you)
  If you have hallucinations or any other abnormal thinking or behavior, talk with your healthcare provider.
  - unusual urges (impulse control or compulsive behaviors). Some people taking NOURIANZ get urges to behave in a way unusual for them. Examples of this are unusual urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges.
  If you notice or your family notices that you are developing any new or unusual symptoms or behaviors, talk to your healthcare provider.
  
  The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia).
  
  These are not all the possible side effects of NOURIANZ.
  
  Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088, or at www.fda.gov/medwatch.
What should my healthcare provider know before deciding if NOURIANZ may be right for me?
- Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you:
  - have a history of abnormal movement (dyskinesia)
  - have reduced liver function
  - smoke cigarettes or use other tobacco products
  - are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby
  - are breastfeeding or plan to breastfeed. It is not known if NOURIANZ passes into breast milk.
    You and your healthcare provider should decide if you will take NOURIANZ or breastfeed
  Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
  
  NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.
  
  Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
How should NOURIANZ be taken?
- - Take NOURIANZ exactly as your healthcare provider tells you to
  - Take NOURIANZ one time each day
  - You can take NOURIANZ with or without food
  - If you take too much NOURIANZ, call your healthcare provider or go to the nearest hospital emergency room right away
What are the ingredients in NOURIANZ?
- The active ingredient in NOURIANZ is istradefylline. The inactive ingredients are crospovidone, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyvinyl alcohol, hypromellose, polyethylene glycol 3350, titanium dioxide, triacetin, iron oxide red, iron oxide yellow, and carnauba wax.
Is there financial support for out-of-pocket treatment costs for NOURIANZ?
- If your doctor has prescribed NOURIANZ and you need help with the out-of-pocket cost, the Kyowa Kirin Cares program may be able to help.
  
  Eligible commercially insured patients may pay as little as $20 for a 1-month supply of NOURIANZ. For full program eligibility requirements, terms, conditions, and limitations, click here.
  
  Kyowa Kirin Cares also provides information, support, and other resources to eligible patients. For more information about Kyowa Kirin Cares, click here.
  
  If you need help paying for NOURIANZ, the Kyowa Kirin Cares program may be able to help you get the information and resources you need to start and stay with NOURIANZ.
  
  Visit Kyowa Kirin Cares for more information, including full eligibility requirements, terms, and conditions.

Organizations for patients with Parkinson’s disease (PD) and their care partners

*Kyowa Kirin proudly sponsors the organization’s initiatives and goals through funding support.

The Michael J. Fox Foundation

www.michaeljfox.org

Dedicated to finding a cure and ensuring the development of improved therapies

Parkinson’s Foundation*

www.parkinson.org

To make life better through improved care and advance research for a cure

American Parkinson Disease Association

www.apdaparkinson.org

Provides information, education, support, activities, events, and referrals

Davis Phinney Foundation For Parkinson’s*

www.davisphinneyfoundation.org

Funds essential information, tools, inspiration for those living with PD, as well as research on exercise, speech, movement, and more

Parkinson & Movement Disorder Alliance

www.pmdalliance.org

Provides opportunities for meaningful connections through
national, independent non-profit funding

Previous:
Getting NOURIANZ

Next:
Care Partner Support

arrow

What is NOURIANZ?

NOURIANZ is a prescription medicine used with levodopa and carbidopa to treat adults with Parkinson’s disease (PD) who are having “off” episodes. It is not known if NOURIANZ is safe and effective in children.

Important Safety Information

Before you take NOURIANZ, tell your healthcare provider about all your medical conditions, including if you:

have a history of abnormal movement (dyskinesia)
have reduced liver function
smoke cigarettes
are pregnant or plan to become pregnant. NOURIANZ may harm your unborn baby
are breastfeeding or plan to breastfeed. It is not known if NOURIANZ passes into breast milk. You and your healthcare provider should decide if you will take NOURIANZ or breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

NOURIANZ and other medicines may affect each other causing side effects. NOURIANZ may affect the way other medicines work, and other medicines may affect how NOURIANZ works.

What are the possible side effects of NOURIANZ?
NOURIANZ may cause serious side effects, including:

uncontrolled sudden movements (dyskinesia). Uncontrolled sudden movements is one of the most common side effects.
hallucinations and other symptoms of psychosis. NOURIANZ can cause abnormal thinking and behavior, including:
- being overly suspicious or feeling people want to harm you (paranoid ideation)
- believing things that are not real (delusions)
- seeing or hearing things that are not real (hallucinations)
- confusion
- increased activity or talking (mania)
- disorientation
- aggressive behavior
- agitation
- delirium (decreased awareness of things around you)
unusual urges (impulse control or compulsive behaviors). Some people taking NOURIANZ get urges to behave in a way unusual for them. Examples of this are unusual urges to gamble, increased sexual urges, strong urges to spend money, binge eating, and the inability to control these urges.

If you notice or your family notices that you are developing any new or unusual symptoms or behaviors, talk to your healthcare provider.

The most common side effects of NOURIANZ include uncontrolled movements (dyskinesia), dizziness, constipation, nausea, hallucinations, and problems sleeping (insomnia).

These are not all the possible side effects of NOURIANZ.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see Patient Information for NOURIANZ.